What Trials are there?

Lots of long haulers are desperate for a cure or some help with symptoms. Some even experiment on themselves after hearing about potential treatments. I would not recommend this, most trials fail to produce positive results and by experimenting on yourself, you will probably do your self more harm than good.

Here I am keeping track of trails on long covid trials. Hopefully in due time some of these will move into the potential treatments page.

At the moment we should let the professionals do the experiments, and not make ourselves the Guinea pigs, espically when we are not properly monitored.

Big well constructed trails, RCT, phase 3 and beyond

Small trails, Phase 2

Case Studies Only, Phase 0-1

Contact me

Location of preregistered studies:

clinicaltrials.gov

ISRCTN registry

Bigger trails, phase 3 and beyond

Involving hundreads or thousands of people, these trails are the one that likely to give solid conclusions about the efficacy of a treatment.

Better studies, towards the top of this section.

Paxlovid

1700 participants, Double blinded, placebo controlled trail, started Jan 2023, due to complete Jan 2025.

Synbiotic SIM01

463 participants, Double blinded, placebo controlled trail.

Very promising results for the use of synbiotic supplements against long covid. This is the most promising data I have seen so far for anything against long covid.

Very encouraging results for alleviation of:
fatigue (p=0·0001, 0.01%),
memory loss (p=0·0024, 0.24%),
difficulty in concentration (p<0·0001, less than 0.01%),
gastrointestinal upset (p=0·0014, 0.14%),
and general unwellness (p=0·0008, 0.08%)
compared with the placebo group.

More Infomation

LAU-7b

Small for a phase 3 trial with only 204 participants. But good prior plausibility along with other anti viral drugs.

Ayurveda

‘Ashwagandha’ (Withania somnifera). Several red flags for Pseudo Science for the back ground. However study protocol shows a large (2500est) and a resonable well designed placebo controlled trial.

However, a big hill to climb as the plausibly is very low and rife with pseudoscience.

Testofen

150 participants, Double blind, placebo controlled trail, due for completion Aug 2025.

Amphetamine-Dextroamphetamine

120 participants, open label, completed Dec 2022, awaiting results

Small trails, Phase 2

Usually Involving less than 100 people, preliminary data.

Studies with higher potential towards to the top,

CBT

Cognitive behavoural therapy, completed study, published online ahead of print.

Naltrexone

160 participants, started May 2023, finished May 2024

Very weak, small unblinded study suggested minor improvement in subjective measures

favipiravir

302 Participants, The primary outcome measure was changed, which is cause for concern.

Mental Health

Exploring the long-term neurological and psychiatric impact of COVID-19.

Nasal Spray

Poor blinding, 22 people, patient reported subjective data.

Nitrite

100 patients, finished Dec 2021, results not posted likely negative.

TENS

Expected to be 96 people still recruiting

Conducted by Newcastle university, website http://www.covidfatigue.co.uk/

Adaptogens

100 patients, surface level is seems to be a good trail design. But a little investigation reveals serious flaws, and the study is negative.

They are claimed to cure everything, even long COVID. But the science on adaptogens is very disappointing.

Medicinal Cannabis

Very small study 12 people, awaiting publication

Homeopathy

A pointless study to see if homoeopathy works for LC. Spolier alert, it doesn't

Case Studies Only, Phase 0-1

Slightly better than, "what someone said on Facebook.”

Hyperbaric Oxygen

The evidence to support HBOT is weak, any benefit is likely short term and very expensive. Probably best avoided unless better evidence comes along.

More information

Sodium Pyruvate Nasal Spray

A phase 1 trail with 22 people. Awaiting results.

Nitrite

An unblinded study with only 40 people that claims to be phase 3. Likely run by people that don't understand trial design.

Creatine

Case study consisting of six people with LC, negative result. Click this link for a breakdown of the study

Nicotine

Case study consisting of four people with LC, positive result.

Online Support

In progress

The bin of other ideas

“What someone said on Facebook.” Phase negative one

These are things that have been mentioned in long covid support groups but there is no science.

Contact me

This list will be continually updated as more evidence comes available. Please contact me for corrections, additions and sugested improvements.

What is long COVID?

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